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Monotreme GLP-1 peptides are resistant to cleavage by human DPP-4 and human serum components but are cleaved in platypus and echidna sera, independently of DPP-4 activity Sequence alignments between human, platypus and echidna GLP-1 proteins (Fig

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Calorie restriction appears to affect neurobiological pathways that control appetite, hunger, cravings and body weight, such that there is increased food intake and weight gain (Brown et al, 2022)

More recently, researchers are trying to understand the connection between active GLP-1 and sweet taste transmission to uncover new treatments for diabetes and obesity 19,20,21,22

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