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The melanotan-1 dosage protocol is therefore structured around receptor saturation kinetics: once MC1R sites are occupied, additional peptide does not accelerate tanning but does increase systemic exposure and side effect probability

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A longer half-life would ensure the increased level of growth hormone production even beyond the initial introduction of the peptide

10.1016/j.febslet.2007.08.032 FEBS Lett

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