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Memantine can be used alone or in combination with cholinesterase inhibitors and has been shown to offer symptomatic relief in mild to moderate cases of VaD and AD, but there are no studies showing its efficacy in MD, although the symptom relief from the studies does suggest it could be a potential treatment for patients with MD 122

It can be used alongside caloric restriction without exacerbating hunger, combined with exercise programs without compromising fueling needs, or integrated with behavioral nutrition approaches that rely on intact hunger and satiety signaling for long-term habit formation

Funding The authors wish to acknowledge funding the Research Support Fund at Hospital de Clnicas de Porto Alegre (FIPE-HCPA) MH, Fundao de Amparo Pesquisa do Estado de So Paulo (FAPESP 2013/13691-1) RM

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