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2.2 Mechanism of ferroptosis occurrence 2.2.1 Core regulatory pathways 2.2.1.1 System xc /GSH/GPX4 signaling as primary regulatory hub Ferroptosis regulation is widely recognized as primarily involving the constitutive inhibition of system Xc , which triggers a cascade leading to glutathione (GSH) exhaustion and GPX4 functional impairment

The 3 top minerals to make glutathione are zinc, selenium, and sulfur

Its cardiovascular focus may complement other anti-aging strategies

Gastrointestinal effects GI side effects dominate the adverse event profile, consistent with all GLP-1 receptor agonists