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FIGURE 3 Mammalian CBS is an unusual PLP enzyme that contains a heme cofactor and S -adenosyl-L-methionine (SAM)

The combination of the AuNPs and photothermal therapy markedly decreases microvascular density in the tumor area, thereby inhibiting the growth of trastuzumab-resistant breast cancer cells via anti-angiogenesis, and ultimately reversing resistance to trastuzumab 87 ( Table 1 )

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