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doi:10.7759/cureus.58720 6

Additional Considerations for GLP-1 Medication Patients The Dosage-Diet Connection Higher doses tend to cause stronger appetite suppression, which can lead to inadequate nutrition

A: Repeated freeze-thaw cycles can cause peptide degradation and loss of bioactivity

Summary and future considerations Despite delivering significant weightloss and health benefits, GLP1 medications also present important limitations, including gastrointestinal side effects, nutrient shortfalls from the diet, loss of muscle mass, high costs, frequent discontinuation, and weight regain once treatment stops

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Metoclopramide should be used with caution due to its FDA boxed warning for tardive dyskinesia and should be limited to short durations (generally less than 12 weeks)