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When ultraviolet rays penetrate the skin and damage DNA, thymidine dinucleotide (pTpT) fragments from damaged DNA will trigger melanogenesis [26] and cause the melanocyte to produce melanosomes, which are then transferred by dendrites to the top layer of keratinocytes
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Tsukumo DM, et al
We also confirmed these results in a parallel experiment by determining a 2.6 cryo-EM reconstruction of PV3-SC8 bound to GSH and an alternative VP1 hydrophobic pocket binding drug, pleconaril (Supplementary Figs
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