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Moreover, the metal nanoprodrug NPS-G-Fe produced by coordinating Fe 3+ and gallic acid (GA) with Ce6 in photoactivated Pt(IV) containing nanoprodrug and then coating with PEG-modified chondroitin sulfate (PEG-CS) can lead to iron dissociation under acidic tumor microenvironment conditions, and NPS-G-Fe can promote macrophage polarization to M1 phenotype after radiotherapy thereby enhancing anti-tumor efficacy (35)