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[15] GLP-1 medications facilitate weight loss primarily through reducing appetite and caloric intake and slowing gastric emptying to prolong satiety

When fat stores run low, the brain detects low levels of leptin and kicks on your appetite you get hungry

Inflammatory macrophages and microglia then perpetuate damage by phagocytosing myelin and releasing cytotoxic mediators

Your weight loss stalls , your appetite suppression weakens, and you start wondering if the medication even works at all