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More chronic, placebo-controlled human studies are required to evaluate not only the bioavailability and efficacy of various polyphenol formulations and delivery systems but also to establish standardized dosages, monitor potential side effects, and assess inter-individual differences in responses due to genetics and gut microbiota composition (126, 127)

doi:10.1007/s10620-021-07163-3

Finally, the in vivo mechanistic studies confirmed the modulation of MAPK and NF-B signaling pathways

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