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doi: 10.1182/blood-2004-02-0446 113 SimardJCSimonMMTessierPAGirardD

The in vitro studies formed the foundation of the investigation

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When given at very high doses nicotinic acid and niacinamide are found unchanged in the urine, suggesting that the capacity to methylate them has been saturated.*[35] *Well discuss this metabolism and elimination in more detail in a subsequent article, focusing in part on what it might imply for dosing and the bodys elimination mechanisms