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But losing weight isnt as simple as calories in versus calories out. Beyond just diet and exercise, excess weight is a complex medical condition driven by deeply intertwined psychological and hormonal factors

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[5] [6] In the SURMOUNT trials for weight management, constipation rates were even higher, affecting approximately 17-26% of participants

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That does not mean the medication failed. It means obesity and weight regulation are biological, chronic, and complex for many people