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In macrophage models, -KG promotes JMJD3-mediated H3K27me3 demethylation, thereby favoring the expression of M2-related genes, whereas succinate accumulation can inhibit demethylase activity and sustain a pro-inflammatory transcriptional state (38)

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Consequently, nonpalmitoylated PD-L1 is subjected to increased ubiquitination and subsequent lysosomal degradation, which ultimately remodels the anti-tumor immune response [168]

tb ( A potential adjunct therapy is glutathione (GSH)

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