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It has been reported that PPAR- expression decreased in a rat model of non-alcoholic fatty liver disease [27] and the absence of PPAR- have been demonstrated to cause lipid accumulation in liver of rats [28]

GLP-1 receptor agonists offer notable benefits for individuals at high risk of cardiovascular issues

However, we assume that cost-effectiveness evaluations may vary from one population to another and according to the disease burden, and such findings may differ for the population for whom a combination of GLP-1RAs and SGLT2is is suitable

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Furthermore, the design presents a promising approach for leveraging bioactive linear peptides

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