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This effect was achieved through the gutbone axis (promoting the growth of Bifidobacterium longum , repairing intestinal mucosal barrier, inhibiting pro-inflammatory cytokines, and restoring Treg/Th17 balance in bone tissue), helping to inactivate the osteoclasts

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Equal amounts of toehold probes were mixed, and the final mixture was diluted to obtain the desired probe concentration (10 pmoles)

Compounded products carry additional uncertainty around manufacturing consistency relative to FDA-approved finished drugs

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