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Only by maintaining a caloric deficit via food or maintaining a higher level of physical activity will the individual be able to maintain the weight they lost on GLP-1s

Additionally, the proportion of exposure variance explained by instrumental variables was evaluated using R 2 , computed as R 2 = 2 EAF (1 EAF) 2 , where EAF denotes the effect allele frequency of the exposure

Individual mice ranged from 51 to 191 days of age

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These results demonstrate that GLP-1 may preferentially alleviate dysregulated glucose uptake and glycogen metabolism in skeletal muscle in the context of obesity by rescuing deficits in AKT/PI3K signaling, but not in conditions of T2DM or normal physiology