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a Simultaneous participation in any other clinical trial receiving an investigational medicinal product b Patients who attended the final scheduled visit c Patients who completed treatment with assigned treatment according to the end-of-trial form Note: Rescue medication = use of new anti-diabetic medication as add-on to treatment and used for more than 21 days with the initiation at or after randomization and before last day on treatment Table 25: Patient Disposition (CVOT) CV = cardiovascular

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The Journal of Clinical Endocrinology & Metabolism , 102(7), 23492355

Effects on curvature and plaque were not evaluated in the randomized phase but curvature improvements were noted in 23% of patients and plaque reductions in 47% of patients in the open-label phase

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Furthermore, it significantly decreased aldosterone concentrations, a known predictor of increased cardiovascular mortality risk, which would indicate AT1R blockade ( Finally, the prevalence of primary aldosteronism (PA), the most common form of secondary hypertension, is reported to be 11-14% in patients with diabetes and hypertension