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The article reports roughly 20 percent body weight reduction at 10 mg weekly against about 21 percent at 15 mg in the trial data it cites, and calls the marginal additional benefit at the maximum modest

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the PYD domain of ASC interacts with the PYD of inflammasomes, and its caspase activation domain and CARD domain interact with the CARD of Caspase-1 to form the NLRP3 complex

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