F.ClarkeG.et al
Neutralize free radicals before they become harmful to cells
On the other hand, Fe(II) ion chelation can significantly influence the properties of flavonoids, such as anti-ROS efficacy, hydrophobicity, and membrane permeability, and, thus, their physiological activity [98,103,104]
Antibiotics should be avoided in the absence of superinfection
Key priorities include doseresponse optimization for acute versus chronic phases, inclusion of biomarkers such as glutathione reductase activity, neuroinflammatory cytokines, and imaging-based lesion metrics, and development of formulations that improve central nervous system bioavailability
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