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An example of this is the discovery by American scientist Kastin in 1975 that the melanocyte-stimulating hormone (MSH) could cross the BBB

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Studies using dual-energy X-ray absorptiometry (DXA) demonstrate reductions in total fat mass up to 10.9 kg, with particular effectiveness in reducing visceral fatthe metabolically harmful abdominal fat strongly associated with cardiovascular and metabolic disease risk

Such changes are often related to rapid weight loss and reduced skin elasticity, particularly in older adults