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10.1016/0002-9378(91)90580-k 54 SchneiderJ.JimenezE.RodriguezF.del TanagoJ

34,35 Evolution has developed pancreatic alpha and beta-cells to act as the master regulators of metabolism, as their ability to secrete key hormones involved in promoting metabolic homeostasis is determined by nutrient levels in circulation

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Centrilobular (Figures 5459) Sometimes referred to as periacinar necrosis, it consists of irreversible cell death of centrilobular hepatocytes and is often seen after anoxia, or exposure to tannic acid, chloroform, or other hepatotoxic agents (Gopinath, Prentice, and Lewis 1987)