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Larger, longer clinical trials are needed to confirm long term effects
For countries like Colombia, the frequency calculated by the WHO for the variants phenotypically associated with the severe deficiency (Type 2, with lower activity than 10%) is between 3% and 7% 23
MMP-15, matrix metalloproteinase 15
Effects of omega-3 fatty acid supplementation on insulin metabolism and lipid profiles in gestational diabetes: Randomized, double-blind, placebo-controlled trial
Under pro-inflammatory conditions, we observed an improvement in ETC function with NR supplementation in trophoblast cells or placental tissue but not in the mitochondrial content
