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These data suggest that EPACs are induced early in melanomagenesis and contribute to primary tumor growth by regulation of redox homeostasis, mitochondrial ROS, and glycolytic metabolism through activation of mTORC1-HIF-1-TXNIP signaling

Sci 19 (11), 3534 (2018)

According to FDA prescribing information, gastrointestinal adverse events led to treatment discontinuation in approximately 4-7% of patients in clinical trials, with rates varying by dose and indication

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