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however, in multiple macrophage research models, it is associated with IL-10 upregulation, suppression of pro-inflammatory signaling, and tolerance-related phenotypes (55, 56)

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In addition, monocyte-derived macrophages are recruited into the liver during the injury phase mainly through Kupffer cell-generated monocyte chemoattractant protein 1 (MCP-1

on the other hand, other studies have suggested that it alters gut microbiota to favor agmatine production, exerting a neuroprotective effect against epilepsy (96)

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The derivatives were resolved and detected using liquid chromatography/electron spray ionization/tandem mass spectrometry in multi-reaction monitoring mode