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The role of lactate is to modulate neural redox state and energy metabolism, which then serves to indirectly enhance NMDA receptor activity, thus facilitating downstream calcium signaling and synaptic plasticity [100,103,105]

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However, many current studies examining the relationship between RA, oxidative stress, and inflammation seem to share the conclusion that getting those factors under control is critical to stopping the arterial stiffness and damage of the disease

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