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The incidence of adverse effects, particularly gastrointestinal complications, psychiatric disorders, and ocular problems, highlights the critical need for thorough patient assessment and continuous monitoring to ensure both the safety and effectiveness of treatment

A network meta-analysis of 19 randomized controlled trials involving more than 13,000 participants found that tirzepatide had a higher incidence of injection site reactions compared to semaglutide

As a result, a meta-analysis of 13 RCTs revealed that GLP-1 RAs, including liraglutide, semaglutide, and dulaglutide, are associated with a 23% increased risk of rapid worsening of diabetic retinopathy in T2DM (OR, 1.23

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This builds muscle memory and familiarity with the sequence before the needle element enters the picture