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SUMMIT: Tirzepatide and heart failure with preserved ejection fraction SUMMIT (Packer et al., NEJM 2024, NEJMoa2410027, PMID 39555826) randomized 731 patients with heart failure with preserved ejection fraction (HFpEF) and a BMI 30 to tirzepatide up to 15 mg/week or placebo, with a median follow-up of 104 weeks

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Eosinophils are of particular interest in models of allergic airways disease since these are the major effector leukocyte driving pathology (37), which melatonin treatment then also abated ( Figures 1I, J )

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