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Finally, emerging clinical observations such as progression independent of relapse activity and silent progression, now thought to take hold very early in the course, together argue that an underlying cytodegenerative process, likely targeting the myelinating unit, may in fact represent the most proximal step in a complex pathophysiological cascade exacerbated by an autoimmune inflammatory overlay

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Derived from a protective protein sequence, it is frequently referenced in preclinical and in vitro work examining peptide mediated signalling within controlled experimental systems

It is important to consider both the positive and detrimental effects of any treatment type before commencing a treatment plan

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