At the time of the terminal experiments, hemodynamic measurement was performed by using a Mikro-Tip catheter (SPR-407, Millar Instruments, Houston, TX) to obtain left ventricular end-diastolic pressure (LVEDP), left ventricular end-systolic pressure (LVESP), heart rate, maximal slope of systolic pressure increment (+dP/dt) and diastolic pressure decrement (dP/dt)
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On the basis of these findings, the 20 g OD dose was chosen for the phase III program because it appeared to offer the best efficacy-to-tolerability ratio [10]
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Additional evidence suggests that GLP-1R-based therapies may attenuate tumor progression in hepatocellular carcinoma and colorectal cancer through metabolic and anti-inflammatory mechanisms
