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Participants were put on a restricted diet and randomly assigned to receive TE (at doses of 0.25 mg, 0.5 mg, or 1.0 mg) or a placebo once daily

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Immunosuppressive therapy also has shown limited efficacy for PBC, emphasizing the significant role of non-immunological pathology of epithelial cells in the pathogenesis

To address this, we developed a method for the rapid immunopurification of the ER, enabling comprehensive profiling of its proteome and metabolome