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In subcutaneous research protocols, doses of 1 to 4 mg per application are typically employed, with a frequency of 2 to 3 times per week

A point worth flagging: berberine itself, when taken orally, isn't risk-free

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The workaround most experienced providers use: if the patient has not tried a prescription weight-loss medication in the past 12 months, prescribe a 90-day supply of orlistat (available over the counter as Alli, or by prescription as Xenical)

These were patients who: already had atherosclerotic cardiovascular disease or heart failure were 65 or older or had moderate kidney problems