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The epithelium of the gastrointestinal tract is exposed to a variety of trypsin-like proteases that can activate PAR2

doi: 10.1038/nm934 134 SharmaMDBabanBChandlerPHouD-YSinghNYagitaHet al

Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 19902021: a systematic analysis for the global burden of disease study 2021

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In a study published in JAMA Psychiatry in February 2025 that included 48 patients with AUD, researchers found low-dose weekly injections of semaglutide significantly reduced alcohol cravings and nicotine use compared with placebo