A number of important molecules, including Rab27A, melanophilin (MLPH) /SLP homolog lacking C2 domains-A, synaptotagmin-like protein (SLP) 2A/synaptotagmin 2 and myosin Va are involved in the regulation of melanosome transport (130,131)
If this holds true, then UA-lowering drugs may be helpful in prevention/management of diabetes, at least in subjects who are at risk for both hyperuricemia and diabetes
However, interpretation of these signatures may be confounded by kidney function and medication use, and clinical translation will require rigorous external validation, particularly in prospective cohorts and trials specifically designed for DKD
Kouichi Tamura has received honoraria/lecture fee from AstraZeneca, Novartes, Bayer, Otsuka Pharmaceutical, Boehringer Ingelheim, Fuji Pharma, Kyowa Kirin, Ono Pharmaceutical, Sanwa Kagaku, Mochida Pharmaceutical, Kowa, Eli Lilly, Novo Nordisk, commissioned clinical trials, contract research and joint research funding: AstraZeneca, Bayer, Novartis, Chinook, Otsuka Medical Devices, Novo Nordisk, Terumo, Variatris, and Kowa, and, Scholarship donations: Otsuka Pharmaceutical, Bayer, Mochida Pharmaceutical, and Boehringer Ingelheim
Faster decision-making with fewer late-stage failures
One Lipo B injection per week, one Lipo C injection per week, administered on separate days if possible (e.g., Lipo B Monday morning, Lipo C Thursday evening)
