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Research shows that gastrointestinal symptomsnausea, vomiting, constipationare the most frequently reported early effects, typically peaking around 48 hours and often resolving within 12 weeks as the body adapts

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We emphasize that these are in silico estimates intended to guide formulation design and interpretation, rather than in vivo pharmacokinetic measurements

The enteric nervous system is a distributed brain-like bunch of neurons and other cells spread throughout our abdomen that may be able to act independently of our big brain

Some people report new sadness, irritability, or loss of interest during treatment, while rarer reports mention suicidal thoughts or self-harm ideation

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