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( 1S,3R )-RSL3 forms covalent bonds with GPX4, which is inactivated via alkylating the selenocysteine and leads to toxic lipid peroxides buildup, and inevitable cell death (Yang et al., 2014

TB-500 TB-500 is a synthetic version of the naturally occurring thymosin beta 4 (TB4) protein, which is found in almost all human cells

A major translational hurdle is the development of agents that can effectively cross the BBB to reach central auditory structures

doi: 10.1159/000371350 30

Dosing begins at 2.5 mg weekly and is gradually increased over several weeks (2.557.51012.515 mg) to minimise gastrointestinal side effects, with maintenance doses ranging from 5 mg to 15 mg depending on individual response and tolerability

Clark, D