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However, the injection frequency is only once a week, which can make them more tolerable

For example, individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2) should not take GLP-1 medications due to an increased risk of thyroid tumors

PubMed McArdle, J.J., Angaut-Petit, D., Mallart, A., Bournaud, R., Faille, L., & Brigant, J.L

Meta-Analysis 878 Patients (PMC, 2025): Across three randomized controlled trials, Retatrutide significantly reduced body weight by a mean difference of 14.33%, BMI by 5.38 units, and waist circumference by 10.51 cm versus placebo

But verify their recommendation is not financially motivated