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Extravascular hemolysis Extravascular hemolysis Hemolytic Anemia would be due to splenic clearance of the deformed RBCs Deformed RBCs Erythrocytes: Histology

10.1056/NEJMoa1607141

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Abstract: Njlsson R

Substrates were added in a stepwise fashion in the following order (final concentrations) 0.2 mM palmitoyl carnitine, 1 mM malate, 4 mM ADP, 0.4 mM octanoyl carnitine, 5 mM pyruvate, 10 mM glutamate, 10 mM succinate, 1 M CCCP, 2 M rotenone, and 5 M Antimycin A