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Although these changes indicated an enhancement of the antioxidant defense system, no clinical improvement in FM symptoms was observed

Further, the reduction in colony formation upon silencing LDHB could be partially rescued by supplementation with the small molecule ferrostatin-1 (FER1), a lipid hydroperoxyl radical scavenger, which inhibits iron-dependent lipid peroxidation 13,34 (Fig

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Patients had a mean PANSS total score of 103 (range 82 to 144) and a CGI-S score of 5.2 (markedly ill) at entry

Additionally, proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of low-density lipoprotein receptor (LDLR) activity, increasing circulating LDL cholesterol (LDL-C) levels by regulating LDLR degradation (ODonoghue et al., 2022)