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In the most of the studies the primary endpoint is a change in HbA1c from baseline, except for the SURPASS J combo, where the primary endpoint is the number of patients with more than one critical adverse event (69, 70)
IV therapy starts with the insertion of a small, sterile needle into a vein, typically on the arm
While a few smaller peptides or those with special modifications might have slightly better oral bioavailability, injectable administration remains the gold standard for most peptide research to ensure efficacy.
Future prospective studies are needed to quantify the efficacy and better understanding the cellular mechanisms of GLP-1 RAs on lymphedema
