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After treatment with CPP-CAND, a significant reduction of approximately 7.1-fold in the number of FOXO4 foci was observed in the nuclei of the senescent cells

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However, the limitations of animal models, the lack of long-term follow-up data, single-dose experiments (1.2 mg/kg), and the lack of mechanistic studies limit the generalizability and reliability of the results

doi: 10.1136/gutjnl-2013-304833 196 SegainJPRaingeard de la BltireDBourreilleALerayVGervoisNRosalesCet al