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In the STEP 1 extension study, withdrawal of semaglutide was followed by substantial weight regain and partial reversal of cardiometabolic improvements, suggesting that short-term pharmacologic weight loss may not be durable without a maintenance strategy ( Finally, clinicians should remain attentive to less common but clinically important safety concerns, including gallbladder disease and pancreatitis-related warnings

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Eur J Pharmacol (2012) 674(2-3):2806

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Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (736 amide) in type 2 (non-insulin-dependent) diabetic patients Diabetologia 1993 36 : 741744

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