fda compounding semaglutide warning september 2025 Compound versions of GLP-1 drugs for weight loss halted by The FDA has received reports

Human trials show major body-weight reductions, with some evidence suggesting results may approach the 30% range

doi: 10.1056/NEJMoa1509225 251 HolmanRRBethelMAMentzRJThompsonVPLokhnyginaYBuseJBet al

Key safety observations from available trial data include: Elevated resting heart rate in a dose-dependent manner Gastrointestinal adverse effects (nausea, vomiting, diarrhoea) as the most common side effects, consistent with the GLP-1 receptor agonist class [1] [3] No clinically significant QT interval prolongation was reported in available data, though the extent of formal thorough QT assessment has not been fully detailed in published sources

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