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Their medical use remains under evaluation, and clinical guidance is necessary before considering them for skin health purposes

JAMA 304 , 435442 (2010)

Tirzepatide activates two hormone receptors simultaneously: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide)

Toxicol Rep 6:12731280 [DOI] [PMC free article] [PubMed] [Google Scholar] Cetinkaya Y, Ger H, Menzek A, Gulcin I (2012) Synthesis and antioxidant properties of (3,4-dihydroxyphenyl)(2,3,4-trihydroxyphenyl)methanone and its derivatives

We also analysed whether persistent GLP-1RA users experienced fewer cardiovascular outcomes and lower all-cause mortality than non-persistent patients

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