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How clinicians might think about this (risk vs benefit) GLP-1 receptor agonists have benefits that are not small: strong glucose lowering in many patients weight loss benefits in certain populations, cardiovascular risk reduction sometimes improved adherence compared to multiple daily pills because of weekly dosing options So for many patients, the benefit side of the equation is heavy

Without Tesamorelin: Semaglutide creates deficit, body burns mostly subcutaneous fat, belly remains disproportionate

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It reduces glucagon, decreasing excess glucose production from the liver

Promoting glycogen breakdown: It encourages the conversion of stored glycogen into glucose, making energy readily available

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