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Under the ROS...thiol network is the principal suspect for autophagy commitment

33 For young adults (age 2039), a 2018 expert panel recommended cholesterol-lowering therapy for those with LDL cholesterol over 160 mg/dL and a history of early-onset atherosclerosis in a close family member

Heterozygous Mmut p.L690Ins/WT mice appear normal compared with wild-type ( Mmut WT/WT ) littermates, and homozygous Mmut p.L690Ins/p.L690Ins mice are characterized in detail in the Results section

Lancet 366 , 649659 (2005)