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For example, certain GLP1R variants correlate with differential appetite suppression response, while FTO variants may relate to baseline metabolic risk
Through the Optum Rx Weight Engage program, the PBM is aiming to support employers and other clients in designing benefits for their membership
Patients with high-sensitivity GLP1R variants sometimes tolerate slower dose escalation better, while those with lower-sensitivity versions may achieve results faster with fewer GI complaints
Harmony Outcomes committees and investigators
In TRIUMPH-1 it occurred in 12.5% of participants on 12 mg, compared to under 1% on placebo
