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The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: evidence from human genetic association studies and a mouse model of alcohol dependence

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J Diabetes Res 2024:5151171

Newer data suggest a significant reduction in cardiovascular events with GLP-1 agonist therapy in patients who are overweight or obese and have a prior history of heart disease

Moderate and high intensity exercise have been shown to increase GLP-1 production for both healthy individuals and those with obesity

The practical consequence is the distinctive focus experience that Lightning reviews consistently describe: not the immediate sharp alertness of caffeine, but a building, deepening mental clarity that intensifies through the session peaking around the midpoint of a training session when cognitive demand from fatigue is highest