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Importantly, the metformin-mediated metabolic alterations demonstrated in rectal cancer in vitro , were also supported in vivo , with metformin demonstrated to significantly inhibit oxidative phosphorylation and glycolysis in treatment nave rectal cancer tissue biopsies

Psychiatry 77 , e1117e1123 (2016)

Mitochondrial autophagy is potentially beneficial in counteracting T cell exhaustion by removing damaged or inefficient mitochondria and promoting the generation of new mitochondria

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