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The cellular and molecular bases of leptin and ghrelin resistance in obesity

Reduction in proteasome functionality may lead to the accumulation of toxic protein, which can be detrimental to cardiac tissues [5]

Methodology was followed as outlined in the manufactures protocol for the Human GPX3 ELISA Detection Kit (NOVUS Biologicals)

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Each parameter was drawn independently from a loguniform distribution, with a range that was set to generate a symmetric 10fold range around the initially set value (shown in Appendix Table S1)