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Pi-Sunyer, X, Astrup, A, Fujioka, K, et al
It has been proven that single NG neurons express multiple receptors for anorectic substances, for example GLP-1R, cholecystokinin A receptor, and leptin receptor 7,29 , but it remains unclear whether orexigenic GHSR coexists with anorectic receptors
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), currently approved for the treatment of type 2 diabetes mellitus, obesity, and obstructive sleep apnea, have recently emerged as potential new pharmacotherapies for ASUDs
Among adults who take the medications, about half say its difficult to afford the cost, according to a May 2024 survey by the health policy group KFF
doi: 10.1016/j.jnutbio.2018.07.009 70 ZhaoLChenYXiaFAbudukerimuBZhangWGuoYet al
70 For example, compound 2j, a triazole-containing derivative, has demonstrated high potency and comparable efficacy to danuglipron in preclinical studies, suggesting it could serve as a lead compound for further development
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